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Role of lubricin and boundary lubrication in the

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Role of lubricin and boundary lubrication in the .

Lubricin, a mucinous glycoprotein produced by synovial cells and superficial zone chondrocytes (11, 14), provides lubrication in the boundary mode . Boundary lubrication dominates during periods of high load and low velocity, when the lubricant film layer is thinner than the surface roughness .

Role of lubricin and boundary lubrication in the .

Osteoarthritis is a complex disease involving the mechanical breakdown of articular cartilage in the presence of altered joint mechanics and chondrocyte death, but the connection between these factors is not well established. Lubricin, a mucinous glycoprotein encoded by the PRG4 gene, provides boundary lubrication in articular joints. Joint friction is elevated and accompanied by accelerated ...

Full-Length Recombinant Human Proteoglycan 4 Interacts .

Abstract. Proteoglycan 4 (PRG4) is a mucin-like glycoprotein present in synovial fluid and at the surface of articular cartilage. The objectives of this study were to (1) assess the articular cartilage surface adsorption and in vitro cartilage boundary lubricating ability of full-length recombinant human PRG4 (rhPRG4), and (2) cartilage boundary lubricating ability of purified rhPRG4, both ...

2. Definition, Function, and Structure of Lubricin and Its .

The boundary lubrication of the surfaces has also been studied, and the role of lubricin and HA (polyelectrolyte) during the initiation and progression and later stages of wear has been investigated in their experiments.

Lubricin: a novel potential biotherapeutic approaches for .

Therefore, a treatment with lubricin which would protect cartilage in vivo would be desirable. This article reviews recent findings with regard to the possible role of lubricin in the progression of OA, and further discusses lubricin as a novel potential biotherapeutic approaches for the treatment of OA.

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptos

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis Kimberly A. Wallera, Ling X. Zhangb, Khaled A. Elsaidc, Braden C. Fleminga,d,e, Matthew L. Warmanf,g, and Gregory D. Jaya,b,h,1 aCenter for Biomedical Engineering and the School of Engineering, Brown University, Providence, RI 02912; bEmergency Medicine Research Laboratory, Department of Emergency Medicine ...

Transcription, Translation, and Function of Lubricin, a .

Lubricin plays a critical role as a boundary lubricant in articulating joints. 1-4 This amphiphilic glycoprotein, which is also called superficial zone protein, ... Boundary lubrication may also be dominant at the cornea–contact lens interface where there is a relative lack of aqueous tear.

Lubricin - Brown Universi

provides lubrication but does not prevent wear, enabling a pencil to leave a residue (writing). Lubricin lubricates via the boundary mode which is a regime in the leftward area of the Striebek curve (Márton & Lantos, 2006). This means that boundary lubrication functions independently of synovial fluid viscosity.

Galectin-3 Binds to Lubricin and Reinforces the .

Effective boundary lubrication by lubricin is dependent upon both its ability to adsorb to articular cartilage 11,12 and the presence of O-linked β(1–3)Gal-GalNAc oligosaccharides 13; however ...

Anti-Inflammatory Role of Lubricin/Proteoglycan 4 (PRG4 .

Background/Purpose: Lubricin/proteoglycan-4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblast and superficial zone chondrocyte. PRG4 has a homeostatic multifaceted role in the joint including boundary lubrication, friction lowering of apposed cartilage surfaces and prevention of synovial overgrowth. PRG4 is abundant in the synovial fluid (SF) and its levels are reduced in SF ...

Boundary-Lubricating Ability and Lubricin in Synovial .

In conclusion, this study showed that distinct changes in lubricin and boundary-lubricating ability in the SF occurred with different stages of TMDs. Further studies should elucidate the role of lubricin, boundary lubrication, and complex, intrinsic mechanisms implicated in TMDs.

Lubricin: a novel potential biotherapeutic approaches for .

Therefore, a treatment with lubricin which would protect cartilage in vivo would be desirable. This article reviews recent findings with regard to the possible role of lubricin in the progression of OA, and further discusses lubricin as a novel potential biotherapeutic approaches for the treatment of OA.

The role of lubricin in the mechanical behavior of .

Recently, many such research concerning role of lubricin and boundary layer lubrication have been analyzed with respect to the lubrication and wear mechanisms observed in synovial joints and ...

Role of lubricin and boundary lubrication in the .

The contribution of boundary lubrication may be dictated by factors such as surface chemistry, roughness [16], and the adsorption of lubricating molecules, such as lubricin [14,[17][18][19].

Proteoglycan 4 - Wikiped

Function. Lubricin is present in synovial fluid and on the surface (superficial layer) of articular cartilage and therefore plays an important role in joint lubrication and synovial homeostasis.When first isolated, cartilage lubricin was called "superficial zone protein" (SZP). Lubricin, MSF, and SZP are now collectively known as Proteoglycan 4 (hence PRG4 for the gene nomenclature).

Boundary lubrication of articular cartilage: Role of .

Accordingly, boundary lubrication has been postulated to be critical to cartilage homeostasis by facilitating low friction and low wear . Future studies of the postulated role of boundary and other modes of lubrication in arthritic disease are needed.

Anti-Inflammatory Role of Lubricin/Proteoglycan 4 (PRG4 .

Background/Purpose: Lubricin/proteoglycan-4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblast and superficial zone chondrocyte. PRG4 has a homeostatic multifaceted role in the joint including boundary lubrication, friction lowering of apposed cartilage surfaces and prevention of synovial overgrowth. PRG4 is abundant in the synovial fluid (SF) and its levels are reduced in SF ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptos

Lubricin, a mucinous glycoprotein encoded by the PRG4 gene, provides boundary lubrication in articular joints. Joint friction is elevated and accompanied by accelerated cartilage damage in humans and mice that have genetic deficiency of lubricin.

The role of lubricin in the mechanical behavior of .

The role of lubricin in the mechanical behavior of synovial fluid. Jay G.D., Torres J.R., Warman M.L., Laderer M.C., Breuer K.S. Synovial fluid is a semidilute hyaluronate (HA) polymer solution, the rheology of which depends on HA-protein interactions, and lubricin is a HA-binding protein found in synovial fluid and at cartilage surfaces, where it contributes to boundary lubrication under load.